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Cerebral Blood Flow Characteristics Responses Following Acute Aerobic Exercise in Individuals with and without Down Syndrome
Author(s) -
Wee SANG OUK,
Schroeder Elizabeth C.,
Grigoriadis Georgios,
Bunsawat Kanokwan,
Rosenberg Alexander J.,
Griffith Garett,
Baynard Tracy,
Fernhall Bo
Publication year - 2018
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.2018.32.1_supplement.712.7
Subject(s) - cerebral blood flow , medicine , cardiology , hemodynamics , blood pressure , aerobic exercise , dementia , heart rate , middle cerebral artery , population , diastole , blood flow , mean arterial pressure , intensity (physics) , ischemia , disease , physics , quantum mechanics , environmental health
Individuals with Down Syndrome (DS) commonly experience low to moderate levels of cognitive impairment and are at a high risk of developing dementia and Alzheimer's diseases (AD). Reduced cerebral blood flow (CBF) and altered CBF characteristics have been observed in the aging population without DS and has shown to have detrimental effects on cerebral microvasculature, which may increase the risk of developing dementia and AD. However, differences in CBF and its characteristics between individuals with and without DS and its response to exercise have not been studied. Purpose To examine the differences in CBF and its characteristics following a 20‐minute bout of moderate intensity walking in individuals with and without DS. Methods Thirty‐eight young (DS=19, Age=25 yrs) individuals with and without DS participated in this study. Changes in mean middle cerebral artery velocity (mMCAv), mMCAv characteristics (pulsatility index (PI), resistance index (RI)) and hemodynamic variables were measured before, immediately post and 30‐minute post exericse. Results Baseline hemodynamics, systolic blood pressure (BP), diastolic BP, mean arterial pressure (MAP), heart rate (HR) and mMCAv were not different between the DS and control group ( p >0.05 for all). Neither group showed changes in mMCAv after moderate intensity treadmill walking exercise ( p >0.05). However, the DS group exhibited significantly higher PI and RI at all time points when compared to controls ( p <0.05 for both). Conclusions Our results demonstrate that CBF was not altered in individuals with DS at rest and following moderate intensity exercise and was not different from that of controls. However, higher PI and RI in DS group may be associated with reduced distal cerebral perfusion and microvascular damage in individuals with DS.DS (N = 19) Control (N = 19)Baseline Immediate post EX 30‐minute post EX Baseline Immediate post EX 30‐minute post EXSBP (mmHg) 122±14 126±11 * 121±13 120±10 130±12 * 121±11DBP (mmHg) 69±9 75±8 * 70±9 72±6 81±8 * 74±9MAP (mmHg) 93±10 98±8 * 94±9 94±7 103±7 * 96±8mMCAv (cm/s) 64.3±14.9 62.8±13.9 60.8±14.6 69.4±13.1 69.8±14.8 69.6±14.1PI ‡ 0.97±0.14 1.04±0.19 1.02±0.14 0.87±0.12 0.89±0.15 0.86±0.14RI ‡ 0.60±0.05 0.61±0.06 0.61±0.05 0.56±0.05 0.56±0.05 0.55±0.05‡ Significant group difference, * Significant time difference from the baseline. Mean ± SD, Significance level, p < 0.05This abstract is from the Experimental Biology 2018 Meeting. There is no full text article associated with this abstract published in The FASEB Journal .