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Cerebrovascular Reactivity in Obstructive Sleep Apnea: Impact of Physical Activity
Author(s) -
Sauder Christina J.,
Carter Katrina J.,
Ward Aaron T.,
Morgan Barbara J.,
Hagen Erika W.,
Peppard Paul,
Schrage William G.
Publication year - 2018
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.2018.32.1_supplement.712.17
Subject(s) - medicine , obstructive sleep apnea , cardiology , continuous positive airway pressure , polysomnography , linear regression , stroke (engine) , blood pressure , anesthesia , apnea , mechanical engineering , machine learning , engineering , computer science
Background Obstructive sleep apnea (OSA) is associated with increased risk of cerebrovascular disease and stroke. This risk may be partially due to reduced cerebrovascular function. Conversely, regular physical activity (PA) reduces the risk for cerebrovascular disease. Whether PA levels can predict the OSA‐related reductions in cerebrovascular function remains unknown. Therefore, we tested the hypothesis that the level of PA alters the relationship between OSA‐severity and cerebrovascular dysfunction. Methods 245 healthy adults (113 females; mean age ~60 years; smoking, continuous positive airway pressure (CPAP) treatment, and diabetes were exclusionary) performed overnight polysomnography to determine the presence and severity of OSA. Next, cerebrovascular function was tested in the middle cerebral artery (MCA) in response to CO 2 rebreathing (10 mmHg increase), expressed as cerebrovascular reactivity (CVR; cm/sec/mmHg P ET CO 2 ). PA was estimated using the Paffenbarger Physical Activity Questionnaire and expressed as Metabolic Equivalent (MET) hours per week. Data were analyzed by linear regression analysis using CVR as the outcome variable and mean nighttime arterial oxygen saturation (SaO 2 ) as the main independent variable. Model adjustments included age, sex, number of metabolic syndrome factors, number of caffeinated beverages per day, and mean arterial pressure (MAP) slope response to CO 2 . We also included a model that had an additional adjustment for PA. Results In an unadjusted model, higher nighttime SaO 2 was a predictor of higher CVR ( p < 0.05). When adjusted with the aforementioned variables, both SaO 2 and MAP slope were predictors of CVR. Adding PA to the adjusted model did not change the overall relationship between SaO 2 and CVR. Conclusions These data fail to demonstrate that PA level has a substantial impact on CVR in subjects with OSA. Support or Funding Information R01HL062252, R01HL075035, and UL1RR025011 This abstract is from the Experimental Biology 2018 Meeting. There is no full text article associated with this abstract published in The FASEB Journal .