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New Paradigms of Mass‐Action Law Based Bio‐Dynamics and Pharmacodynamics for New Drug Evaluations
Author(s) -
Chou TingChao
Publication year - 2018
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.2018.32.1_supplement.690.4
Subject(s) - pharmacodynamics , action (physics) , computer science , pharmacology , mathematical economics , medicine , mathematics , physics , pharmacokinetics , quantum mechanics
The Mass‐action law (MAL) based Median‐effect eq. (and its Combination‐index eq.) is the unified general biodynamics (BD) theory for biochemistry and biophysics (Chou TC, Pharmacol. Rev. 58: 621–681, 2006; Integr. Biol. 3: 548–559, 2011). Its eqs & algorithms provide efficient, quantitative, econo‐green, digital, automated computer simulations for bio‐medical research & development (R&D). This paper is to illustrate the fundamental principle of how the theory was derived during the 1967–1984 period, and how this theory, to date has been cited 27,594 times in >1,500 biomedical journals worldwide (Google Scholar Citations – Ting‐Chao Chou; Web of Science: www.researcherid.com/rid/B‐4111‐2009 ). One theoretical article alone, Chou TC & Talalay P, (Adv. Enz. Regul. 22: 27–55, 1984) has been cited 5,422 times in 1,102 journals, which is referred as “Makes History” [Elsevier News Release 3/16/2016]. The derived/proven theory reveals the following new basic paradigms: 1. “ Dose” and “Effect” are interchangeable . 2. All dose‐effect curves (DEC) of MAL can be transformed into straight lines . 3. The theoretical minimum of only 2‐data points are required to simulate a DEC [and the practical minimum of 16, 10, and 10 data points for a DEC by computer simulation in vitro, animals and clinical trials, respectively]. This is the theoretical basis for simple, efficient, quantitative “econo‐green” bio‐R&D and regulations. 4. Explicit digital definition of “Synergism” of drug combination is established [in which “Synergism‐Claim” has scientific, regulatory, legal, ethical and economic consequences]. 5. K i will never be greater than IC 50. 6. The median‐dose ( Dm ) is the harmonic mean of kinetic constants, K ii and K is . 7. The PD software, e.g., CompuSyn, allows 5 dynamic graphic transformations for diagnostic plots, illustrations automatically by computer simulation within 1 second after data entries. This theory/method has been cited 9,916 times during 2012 to 2017. The Scopus Analysis (11.18.2017) indicated that Chou's publications have been cited by the papers distributed in the follow disciplines: Medicine (56.2%), Biochem. (50.8%), Pharmacol. (25.3%), Chem. (15.6%), Immuno. (4.3%), Chemical Engineer. (3.5%), Mater. Sci. (2.1%), and Others (9.3%); and by number of citing papers from Institutions: Mem. Sloan‐Kettering CC (475), Harvard Med. Sch. (380), MD Anderson CC (325), NIH (305), NCI (251), Inserm (200), Chinese Aca. Sci. (155), UC‐SD (130) and Duke U. (127). The above indicate the broad utilities and high impact of the MAL based PD theory and applications. Support or Funding Information PD Science LLC Fund‐17 This abstract is from the Experimental Biology 2018 Meeting. There is no full text article associated with this abstract published in The FASEB Journal .