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Influence of Cigarette Smoking on Myocardial Infarction Induced Renal Damage
Author(s) -
Habeichi Nada,
Abidi Emna,
Alawasi Hiam,
ElYazbi Ahmed,
Zouein Fouad
Publication year - 2018
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.2018.32.1_supplement.679.7
Subject(s) - myocardial infarction , medicine , carcinogen , fibrosis , inflammation , kidney , pathological , secondhand smoke , cardiology , physiology , endocrinology , pathology , chemistry , environmental health , biochemistry
Both, cigarette smoking (CS) and myocardial infarction (MI) remain a major public health concern and a leading cause of cardio‐renal morbidity in both males and females. In addition to nicotine, cigarette smoke contains thousands of carcinogenic and non‐carcinogenic chemicals that play a key role in reducing cell viability in renal proximal tubular epithelial cells through acute or chronic pathological mechanisms. In this study, the impact of CS on renal remodeling in both genders was investigated in a mouse model of MI using 2 groups: MI as a control, and MI + CS. Histological analysis of MI group showed alterations in the kidney structure including patchy glomerular retraction which was heightened by two‐fold post‐CS in both genders. As well, molecular analysis revealed that reactive oxygen species production was significantly accentuated in MI+CS compared to MI group similarly in both genders. These findings indicate that CS aggravates MI‐induced renal damage without an exhibition of gender based differences. In order to get more conclusive results, further molecular analysis is under way to study the role of inflammation, and fibrosis on the observed renal changes Support or Funding Information Supported by AUB Seed fund #10041 This abstract is from the Experimental Biology 2018 Meeting. There is no full text article associated with this abstract published in The FASEB Journal .