Premium
Changes in Spexin Levels are influenced by the Presence or Absence of Gestational Diabetes in Pregnant Subjects
Author(s) -
Aldaghri Nasser
Publication year - 2018
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.2018.32.1_supplement.670.49
Subject(s) - gestational diabetes , medicine , glycemic , pregnancy , anthropometry , obstetrics , adipokine , diabetes mellitus , prospective cohort study , endocrinology , gynecology , physiology , gestation , insulin resistance , biology , genetics
Objective The study aimed to determine whether circulating spexin (SPX) is modified during the course of pregnancy and whether it is affected by the presence of glucose intolerance. Methods This prospective follow up study involved 47 pregnant women (26 non‐GDM and 21 GDM; mean age 31.0 ± 5.4 years; mean BMI 28.2 ± 5.8 kg/m 2 ). Anthropometrics, glycemic and lipid profile as well adipocytokines and spexin were measured at baseline and after 3 and 6 months. Results In GDM patients, SPX levels increased significantly after 6‐months, along with the significant increase in glucose during the same time (p=0.04). In non‐GDM patients, median SPX level decreased significantly from baseline to 6‐months (p<0.01) but no such significant change in glucose was observed. Change in glucose from baseline to 6‐months was significantly and positively associated with change in SPX in GDM patients only (R= 0.45; p<0.05). Conclusions Changes in SPX levels seem to be influenced by the presence of glucose intolerance (GDM) among pregnant women, with decreasing levels among those without GDM, and increasing among those with GDM. Support or Funding Information The study was funded by Prince Mutaib Chair for Biomarkers of Osteoporosis (PMCO), Deanship of Research Chairs in King Saud University, Riyadh, Saudi Arabia This abstract is from the Experimental Biology 2018 Meeting. There is no full text article associated with this abstract published in The FASEB Journal .