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Antioxidant effect of Justicia spicigera in liver from diabetic rats
Author(s) -
MurilloVillicaña Marina,
MartínezMora José A.,
NoriegaCisneros Ruth,
ManzoAvalos Salvador,
SalgadoGarciglia Rafael,
CortésRojo Christian,
MontoyaPérez Rocío,
SaavedraMolina Alfredo
Publication year - 2018
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.2018.32.1_supplement.670.29
Subject(s) - oxidative stress , antioxidant , diabetes mellitus , very low density lipoprotein , medicine , glutathione , endocrinology , catalase , body weight , cholesterol , lipoprotein , pharmacology , chemistry , biochemistry , enzyme
The oxidative stress is a factor that contributes to the development of complications in the diabetes disease; however, its effects can be counteracted by the use of exogenous antioxidants, which are found in some plants. That is why people look to the traditional medicine in search of the therapeutic treatment. Justicia spicigera has been demonstrated to have the capacity of reduce glycemia levels; nevertheless the effects in non‐insulin dependent‐organs like liver, has not been reported. During administration of the ethanol extract for 30 days, the blood glucose and weight data were taken every 5 days. Once the treatment concludes, the rats were sacrificed. The corporal weight, blood glucose, cholesterol‐Very Low Density Lipoprotein (VLDL), triglycerides, total lipids and liver profile; were diminished in the diabetic condition and normalized with the application of ethanol extract of J. Spicigera (EJS). Meanwhile catalase activity shown a significant increase in control diabetic rats and a decrease in their activity with the application of the extract, without any effect in normoglucemic rats. There is also a tendency to increase the GSH/GSSG ratio and a decrease in total glutathione levels in diabetic rats. In conclusion, the ethanol extract of Justicia spicigera is considered to reduce oxidative stress in liver in STZ‐induced diabetes rats. Support or Funding Information This abstract is from the Experimental Biology 2018 Meeting. There is no full text article associated with this abstract published in The FASEB Journal .