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Assessing Glucocorticoid Receptor Polymorphisms in Obese Populations
Author(s) -
Bonnet ClaudeLuvier,
Dowdye Ayanah,
Cohen Brian D.
Publication year - 2018
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.2018.32.1_supplement.670.24
Subject(s) - glucocorticoid receptor , biology , endocrinology , medicine , mineralocorticoid receptor , receptor , glucocorticoid , obesity , gene , single nucleotide polymorphism , genotype , genetics
The glucocorticoid receptor (GR) is part of a family of nuclear receptors that control gene expression. In the presence of the steroid hormone cortisol certain genes are expressed; the products of which control, among other things, blood pressure, serum triglycerides, and blood sugar which are often elevated in patients with obesity. Specific polymorphisms of the GR and other regulators of either GR (or the closely related mineralocorticoid receptor) such as heat shock protein 90 (HSP90) and 11β‐hydroxysteroid dehydrogenase type 1 (11βHSD1) have been found in our labs and others to be present at a higher frequency in obese populations. Our current research is investigating polymorphisms in these genes as well as the gene encoding the FK506 binding protein (FKBP) which works in conjunction with HSP90 to negatively regulate GR activity. It is hypothesized that polymorphisms may exist in the FKBP51 gene that would result in decreased activity of FKBP and subsequent overactivity of GR resulting in phenotypic hypercortisolemia. Analysis of the FKBP51 single nucleotide polymorphism RS1360780 showed a correlation with serum triglycerides, blood pressure, BMI, and weight regain in bariatric surgery patients. This finding in combination with previous results will lead to a better understanding of the genetic underpinnings of obesity and may reveal novel therapeutic approaches. This abstract is from the Experimental Biology 2018 Meeting. There is no full text article associated with this abstract published in The FASEB Journal .