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C. elegans Avoids Toxin‐Producing Streptomyces
Author(s) -
Miller Conrad Laura C.,
Tran Alan,
Tang Angelina,
O'Loughlin Colleen T.,
Balistreri Anthony,
Chang Eric,
Villa Doris Coto,
Li Joy,
Varshney Aruna,
Matthews Sarah,
Bremmer Martina,
VanHoven Miri K.
Publication year - 2018
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.2018.32.1_supplement.669.12
Subject(s) - caenorhabditis elegans , streptomyces , bacteria , biology , microbiology and biotechnology , gene , biochemistry , genetics
Species of the non‐motile bacterium Streptomyces protect themselves from predation by the bacteriovore Caenorhabditis elegans through the secretion of nematicides. To evade death by these agents, C. elegans has evolved the ability to detect and avoid the bacterium. We characterize fatty acid analogs, including dodecanoic acid, which elicit a fast avoidance response by C. elegans . We also detect dodecanoic acid that has been secreted by Streptomyces by derivatization and detection with high resolution mass spectrometry. By sensing these signals, C. elegans can escape the nematicidal bacteria that would otherwise be a good food source. Support or Funding Information Laura Miller Conrad: National Institutes of Health (5SC3GM118199); Angelina Tang and Sarah Matthews: National Science Foundation (HRD‐1302873); Miri VanHoven: National Institutes of Health (NS087544, GM089595), National Science Foundation (1355202). This abstract is from the Experimental Biology 2018 Meeting. There is no full text article associated with this abstract published in The FASEB Journal .