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Investigation of New Chemical Probes for Detection of Citrulline Using Small Molecule Model Systems
Author(s) -
Delaney Brian,
Laufenberg Brandon,
Kadnikov Dmitry V.
Publication year - 2018
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.2018.32.1_supplement.657.10
Subject(s) - citrullination , citrulline , phenylglyoxal , arginine , chemistry , rheumatoid arthritis , computational biology , small molecule , amino acid , biochemistry , medicine , biology , immunology
Citrulline is an amino acid formed via post‐translational modification of arginine. Citrullination of proteins underpins development of such health problems as rheumatoid arthritis, multiple sclerosis, other autoimmune diseases, and perhaps other diseases such as Alzheimer's disease. Current probes based on phenylglyoxal exist but are lacking in stability, are difficult to synthesize, and are expensive to produce. A more viable probe that could properly detect concentrations of citrulline in the body could help with early diagnosis of patients affected by these diseases. The goal of this project is to create new, more stable probes for the detection of citrulline in the body. Currently, new reactive heads based on protected phenylglyoxal have been synthesized and their reactions with small molecules mimicking citrulline are being investigated. This abstract is from the Experimental Biology 2018 Meeting. There is no full text article associated with this abstract published in The FASEB Journal .