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Comparison of 3D Ultrasound Imaging to Computed Tomography in Knee Osteophyte Depiction
Author(s) -
Vendries Valeria,
Ungi Tamas,
Kunz Manuela,
MacKenzie Leslie W.,
Venne Gabriel
Publication year - 2018
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.2018.32.1_supplement.641.6
Subject(s) - medicine , cadaveric spasm , ultrasound , osteoarthritis , radiology , computed tomography , biomedical engineering , anatomy , pathology , alternative medicine
Background Osteophytes (marginal bony outgrowths) are a common radiographic marker of osteoarthritis (OA) and joint degeneration. However, due to their variable morphologic composition, osteophytes are not accurately depicted using conventional imaging modalities. This represents problems for evaluating the anatomical changes of the osteoarthritic joint, and for the design of surgical interventions that rely on the accuracy of pre‐operative images. Studies have shown that ultrasound is a promising tool to detect articular changes such as the presence of osteophytes, and to monitor the progression of OA. Furthermore, 3D ultrasound (3DUS), a tool for volume rendering and surface representation, can potentially offer a means to quantify and depict osteophytes. Objective To compare osteophyte depiction in the knee joint using 3DUS and conventional Computed Tomography (CT) and to evaluate the ability of 3DUS at quantifying osteophyte surface depiction. Methods Eleven fresh‐frozen‐thawed human cadaveric knees were pre‐scanned for the presence of osteophytes according to a previously validated US semi‐quantitative grading system. Five knee sides with visible signs of OA were selected; 3DUS and CT images were obtained, segmented and digitally 3D reconstructed. The knees were dissected and Structured Light Scanner (SLS) images of the physical joint surface were obtained. Using a custom software, surface matching and Root Mean Square Error (RMSE) analyses were performed to assess the accuracy of each of the evaluated modalities in capturing the anatomy of the bone surface at the sites of osteophytes. 3DUS and CT models were compared to the SLS model, which was used as ground truth. Results The average RMSE for 3DUS to SLS and for CT to SLS model comparisons were 0.87 mm and 0.95 mm respectively. No statistical difference was found between 3DUS and CT (p=0.43). Comparative observation of imaging modalities set against each other suggests that 3DUS is superior in depicting osteophytes with cartilage and fibrocartilage tissue characteristics compared to CT. Conclusions 3D Ultrasound can depict features of OA such as osteophytes together with their cartilaginous portion, which is not accurately represented using CT. It is feasible to compare 3DUS to conventional imaging for bone surface depiction within the knee joint. Lastly, 3DUS can provide useful information about not only the presence, but the extent of osteophytes. This abstract is from the Experimental Biology 2018 Meeting. There is no full text article associated with this abstract published in The FASEB Journal .