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N‐3 fatty acids prevent trabecular bone loss
Author(s) -
Sanchez Diego,
Mendez Daisy,
Fernandes Gabriel,
Banu Jameela
Publication year - 2018
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.2018.32.1_supplement.640.2
Subject(s) - ovariectomized rat , metaphysis , tibia , femur , cortical bone , medicine , bone mineral content , endocrinology , chemistry , bone mineral , osteoporosis , anatomy , surgery , estrogen
N‐3 fatty acids have been implicated in preventing bone loss. Whether n‐3 fatty acids can restore bone loss is not established. We conducted a study using the ovariectomized mouse model to determine if n‐3 fatty acids can restore bone. Ten months old, C57BL/6, retired breeder mice were either sham operated or ovariectomized and left for 3 months. The different groups were: Group 1. LC S; Group 2. LC O; Group 3. 18/12 S; Group 4. 18/12 O Group 5. 30/20 S Group 6. 30/20 O. Mice were fed either LC or FO (10%). The LC and FO fed groups were kept in the respective diet regimens for the next 3 months, at the end of which they were sacrificed and long bones were subjected to pQCT analyses. In the distal femoral metaphysis, trabecular bone mineral content (Tb BMC) was decreased significantly in the LC O mice while it was increased in the 18/12 O group. Similarly in the proximal tibial metaphysis, the Tb CNT and cortical bone mineral content were significantly higher in the 18/12 O and 30/20 O groups. In summary, the 18/12 n‐3 fatty acids increased trabecular content in both the femur and tibia and the cortical BMC was increased only in the tibia, suggesting that 18/12 is more beneficial. Support or Funding Information Funding: Engaged Scholarship for Undergraduate Research. This abstract is from the Experimental Biology 2018 Meeting. There is no full text article associated with this abstract published in The FASEB Journal .