Premium
Biomarkers and components of the interactive Physical and Cognitive Exercise System (iPACES™ v2.0) for Mild Cognitive Impairment (MCI): Cortisol, Dehydroepiandrosterone (DHEA‐S), and Insulin‐like Growth Factor (IGF1)
Author(s) -
Wall Kathryn Mary,
Stark Jessica,
KarlaLall Anvit,
Schillaci Alexa,
Christian Hannah,
Doty Carolyn,
McLaren Elizabeth,
Saulnier Tobi,
Cohen Brian D.,
AndersonHanley Cay
Publication year - 2018
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.2018.32.1_supplement.588.25
Subject(s) - stroop effect , cognitive decline , population , cognition , psychology , biomarker , medicine , dementia , dehydroepiandrosterone , placebo , effects of sleep deprivation on cognitive performance , endocrinology , physical therapy , clinical psychology , psychiatry , androgen , pathology , hormone , disease , biochemistry , environmental health , chemistry , alternative medicine
Dementia cases are on the rise among our aging global population, and thus there is increasing urgency to identify efficacious interventions for preserving or ameliorating cognitive decline. Physical exercise, cognitive training and combined physical and cognitive interventions have been found to slow the decline of cognitive abilities in those with mild cognitive impairment (MCI) but the biological mechanisms underlying these changes need further clarification. This quasi‐experimental within‐subjects design compared changes in biomarkers during two‐week exposures to components of the interactive physical and cognitive exercise system (iPACES™). Participants were evaluated over eight weeks at two‐week intervals. Biomarker levels of Cortisol, IGF1 and DHEAS were assessed at each evaluation through saliva (passive drool collection). Each saliva sample was analyzed using enzyme‐linked immunosorbent assays (ELISAs). Additionally, each sample was analyzed using bicinchoninic acid (BCA) protein assay to normalize protein concentration. Cognitive outcomes were also assessed, focusing on executive function via Stroop, Trails, and Flanker tests. This pilot study enrolled 14 older adults, 13 of which met criteria for MCI (MoCA<26), with ten study completers. Paired t‐tests revealed significant ( p s<.05) cognitive improvements in Stroop and Flanker from baseline during all active component conditions (e.g., pedaler, game, and iPACES™), but not during placebo. Biomarkers did not change significantly during placebo or pedaler conditions, but during the game intervention, DHEAS declined significantly ( p =.04), and during iPACES™ intervention, DHEAS declined further and IGF1 declined significantly ( p =.05), consistent with prior research (McTiernan, et al., 2005; Yuichiro, et al., 2010). Furthermore, the changes (from baseline to the end of the 8‐week trial) for cognition were moderately correlated with biomarker changes ( r 's ranging from −.22 to −.48), suggesting a link between neurobiological mechanisms and cognitive outcomes. Further research is needed to replicate and extend this pilot research; in particular, it would be useful to compare such interventions in a randomized controlled trial. Support or Funding Information National Institute on Aging STTR Grant #R41AG053120 and Union College Undergraduate Research Grant This abstract is from the Experimental Biology 2018 Meeting. There is no full text article associated with this abstract published in The FASEB Journal .