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Effects of Yoga based cardiac rehabilitation on Vascular and Endothelial function in patients post myocardial infarction – A randomized controlled trial
Author(s) -
Christa S. Edmin,
Jaryal Ashok Kumar,
Yadav Raj Kumar,
Roy Ambuj,
Chandran Dinu S.,
Deepak Kishore Kumar
Publication year - 2018
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.2018.32.1_supplement.588.23
Subject(s) - medicine , pulse wave velocity , myocardial infarction , cardiology , rehabilitation , cardiac function curve , heart rate , randomized controlled trial , physical therapy , blood pressure , heart failure
Background Vascular and Endothelial dysfunction is an independent predictor of cardiovascular and all cause mortality. We tested the effect of 12‐week Yoga‐based cardiac rehabilitation program on Vascular and Endothelial function in patients following acute myocardial Infarction Methods In this study, 80 patients (50.06 ± 9.43 years) were randomly assigned to either Yoga based cardiac rehabilitation group (YG) or Standard care group (CG) post acute‐myocardial infarction (MI). The YG received a structured yoga based cardiac rehabilitation program in addition to usual care. CG participants received three brief educational sessions. Baseline (at 3 weeks post MI) and post intervention assessments included carotid‐femoral pulse wave velocity (cf‐PWV), augmentation index (AIX@HR75) normalized to heart rate and flow mediated dilation (FMD). All recordings were done in the Autonomic & Vascular function lab, Department of Physiology at AIIMS, New Delhi (CTRI/2017/09/009925). Results Values are expressed as mean change score. After 12 weeks, no significant changes were found between groups in cf‐PWV(−0.29±2.18 vs. −0.18±1.70, p=0.82). AIX@HR75 decreased (0.35±5.08 vs. 3.88±8, p=0.02) and FMD increased (2.72±5.49 vs. −0.14±4.81, p=0.01) significantly in YG than the control group. Per‐protocol analysis (n=52) also provided similar results. There was no significant changes were found between groups in cf‐PWV(−0.84±2.90 vs. −0.12±1.89, p=0.40). AIX@HR75 decreased (−0.85±4.29 vs. 2.13±7.13, p=0.05) and FMD increased (3.36±6.38 vs. −0.28±5.22, p=0.02) significantly in YG than the control group. Conclusions Yoga based cardiac rehabilitation improved endothelial function and functional measure of arterial stiffness significantly. There was no significant change in structural measure of arterial stiffness. This signifies that short term yoga based rehabilitation could improve only the functional measures and may be insufficient to elucidate structural changes over 12 weeks. Support or Funding Information AIIMS, New Delhi, IndiaICMR, New Delhi, IndiaMRC, UK This abstract is from the Experimental Biology 2018 Meeting. There is no full text article associated with this abstract published in The FASEB Journal .