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Exercise Training Improves Metaboreflex Control of Sympathetic Nerve Activity in Obstructive Sleep Apnea
Author(s) -
Guerra Renan Segalla,
Goya Thiago T.,
Silva Rosyvaldo F.,
Barbosa Eline R.F.,
Lima Marta F.,
LorenziFilho Geraldo,
Negrão Carlos Eduardo,
UenoPardi Linda Massako
Publication year - 2018
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.2018.32.1_supplement.588.18
Subject(s) - medicine , microneurography , blood pressure , heart rate , obstructive sleep apnea , cardiology , physical therapy , hemodynamics , polysomnography , apnea , baroreflex
BACKGROUND We have recently demonstrated that patients with obstructive sleep apnea(OSA) have abnormal muscle metaboreflex control of muscle sympathetic nerve activity(MSNA). OBJECTIVE To test the hypothesis that exercise training (ET) would improve muscle metaboreflex control of MSNA in patients with OSA. METHODS 41 individuals with OSA(polysomnography), age = 51±1 years, BMI = 29.5±0.6 kg/m 2 , were randomly divided into untrained (n=21), and trained (n=20) groups. Heart rate, blood pressure, and MSNA(microneurography) were continuously measured during 4 min at rest, 3 min of handgrip static exercise (30% maximal voluntary contraction), and 2 min post handgrip muscle ischemia(PHMI). The metaborreflex sensitivity was evaluated as the difference in MSNA between first and second min PHMI and resting period. ET program was conducted for six months, three session/week. Each session consisted of 45 min of cycle ergometer, 10 min of local strengthening exercise, and 5 min of cool down. RESULTS Baseline age, BMI, exercise capacity, and hemodynamic variables were similar between groups. Likewise, the exercise and PHMI responses were not different between groups. Of note, MSNA returned to baseline during the PHMI period in both groups, which is an indicative of impaired muscle metaboreflex control. ET significantly increased exercise capacity. ET reduced MSNA levels at rest (36±3 vs . 25± 2 bursts/min), and during exercise (43±4 vs . 32± 3 bursts/min). More interestingly, MSNA remained elevated during PHMI in comparison to rest period in the exercise‐trained individuals (29±2 vs . 25± 2 bursts/min). No change in the untrained patients was found. CONCLUSIONS ET decreases sympathetic nerve activity during moderate handgrip exercise and improves muscle metaboreflex control of MSNA in patients with OSA. Supported by FAPESP # 2010/15064‐6 Support or Funding Information FAPESP # 2010/15064‐6 This abstract is from the Experimental Biology 2018 Meeting. There is no full text article associated with this abstract published in The FASEB Journal .