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Effects of acute loaded wheel running on BDNF expression in the rat hippocampus
Author(s) -
Lee Min Chul,
Cha Joo Eu,
Yoo Tae Woo
Publication year - 2018
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.2018.32.1_supplement.587.2
Subject(s) - wheel running , hippocampal formation , hippocampus , turnover , work (physics) , resistance training , psychology , physical medicine and rehabilitation , endocrinology , medicine , physical therapy , engineering , mechanical engineering , management , economics
Voluntary wheel running has beneficial effects on hippocampal cognitive functions if done abundantly. However it is still uncertain whether resistance wheel running would be the same. Voluntary resistance wheel running with a load is a suitable model, since it allows increased work levels and resultant fast‐twitch muscular adaptation. Here we examined whether acute voluntary wheel running with an additional load on BDNF expression in the rat hippocampus. We used 10‐week‐old male Wistar rats and divided randomly into sedentary (Sed), voluntary exercised with No‐load 3) voluntary exercised with additional Load group for acute 1 week. The load for the Load group was increased to reach ~30% of body weight during training. The expression of BDNF genes was quantified by realtime PCR. The relative soleus weights were greater in the No‐Load group. Further, loaded wheel running up‐regulated gene expressions in BDNFmRNA level compared with the Control group. Interestingly, BDNFmRNA levels showed a positive correlation with work load levels(r=0.75), supporting the idea that work levels availability contributes to the BDNF benefits of loaded wheel running revealed in this study. Overall, this novel approach assessing the first time that voluntary loaded wheel running which causes a muscular adaptation, resulted in enhanced gene expression of BDNF, suggesting a possible role of high‐intense short term exercise on hippocampal BDNF actions. Support or Funding Information This work supported by the National Research Foundation of Korea Grant funded by the Korean Government (NRF‐201700310001). This abstract is from the Experimental Biology 2018 Meeting. There is no full text article associated with this abstract published in The FASEB Journal .