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Effect of Endothelin‐Related Gene Polymorphisms on Age‐Related Arterial Stiffening: A 10‐Year Longitudinal Study
Author(s) -
Sugawara Jun,
Tomoto Tsubasa,
Noda Naohiro,
Matsukura Satoko,
Tsukagoshi Kazuya,
Maeda Seiji
Publication year - 2018
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.2018.32.1_supplement.586.11
Subject(s) - arterial stiffness , pulse wave velocity , medicine , snp , single nucleotide polymorphism , longitudinal study , confounding , genotype , cardiology , endocrinology , gastroenterology , biology , blood pressure , genetics , gene , pathology
Increased arterial stiffness has emerged as a strong predictor of future cardiovascular events and all‐cause mortality. The aim of this study was to elucidate influences of endothelin (ET)‐related genetic polymorphisms on age‐related arterial stiffening through a 10‐year longitudinal study. A decadal change in brachial‐ankle pulse wave velocity (baPWV), an index of arterial stiffness, was evaluated retrospectively among 92 volunteers (63 ± 14yrs, 51 men). The targeted single‐nucleotide polymorphisms were ET‐A receptor SNP rs5333 (ET‐A) and ET‐B receptor SNP rs5351 (ET‐B). Subjects with either ET‐A TC or CC genotypes exhibited significantly greater increases in baPWV (+15.3 ± 11.7 and +16.6 ± 15.7%/dec, respectively) than ET‐A TT genotype holders (+9.2 ± 9.0%/dec), while subjects with the ET‐B GG genotype showed a significantly greater increase in baPWV (+17.7 ± 14.1%/dec) than other ET‐B genotype holders (AA: +9.5 ± 10.0%/dec; AG: +11.2 ± 9.6%/dec). The combination of these ET‐related genetic risks was associated with a 2.4 times greater decadal increase in baPWV compared with no genetic risk (+8.1 ± 8.4 vs. 19.5 ± 16.0%/dec). These differences remained significant after adjusting for confounding factors, including baseline baPWV. Our current longitudinal study found that ET‐related gene polymorphisms contribute to diverse age‐related changes in arterial stiffness. Support or Funding Information This study was supported by special coordination funds of the Japanese Ministry of Education, Culture, Sports, Science, and Technology (KAKENHI JP25702045 and JP26670116, to JS). This abstract is from the Experimental Biology 2018 Meeting. There is no full text article associated with this abstract published in The FASEB Journal .