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Growth, Ageing of Coronary Arterial Trees Obey Scaling Laws
Author(s) -
Pei Niu,
Yunlong Huo
Publication year - 2018
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.2018.32.1_supplement.579.9
Subject(s) - scaling , scaling law , exponent , fractal , branching (polymer chemistry) , ageing , china , cardiology , mathematics , medicine , law , materials science , philosophy , mathematical analysis , geometry , political science , linguistics , composite material
Objective Despite the well‐known design principles of vascular systems, it is unclear whether the vascular arterial tree in a given species satisfies some scaling constraints during normal growth and ageing. Method Basing on the micro‐computed tomography measurements of coronary arterial trees in mice at different ages (one week to more than eight months), we present a constant exponent of 3/4, but age‐dependent scaling coefficients in a length–volume scaling law. Results The constant 3/4 exponent represents the self‐similar fractal‐like branching pattern (i.e. basic mechanism to regulate the development of vascular trees for a certain species), whereas the age‐dependent scaling coefficients characterize the structural growth or resorption of vascular trees during normal growth or ageing, respectively. Conclusions This study helps to understanding of age‐associated changes in vascular structure and function. Support or Funding Information This research is supported in part by the Natural Science Foundation of China grant No.11372010 (Y.L.H.) and the China MOST grant No.2014DFG32740 (Y.L.H.). This abstract is from the Experimental Biology 2018 Meeting. There is no full text article associated with this abstract published in The FASEB Journal .