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Decline in conduit artery function across the healthy human adult lifespan: influence of successful aging
Author(s) -
Shields Katherine,
Broxterman Ryan,
Kwon Oh Sung,
Park Sounghun,
Jarrett Catherine,
Smith Ken,
Wray D Walter,
Richardson Russell
Publication year - 2018
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.2018.32.1_supplement.578.5
Subject(s) - brachial artery , medicine , ageing , artery , age groups , cardiology , physiology , demography , gerontology , blood pressure , sociology
While it is well‐established that vascular function decreases with age, potential differences in this decay between typical aging (≈ 70 yrs, many unlikely to become centenarians) and highly successful aging (>90 yrs, with preserved physical and cognitive health) remain unknown. Therefore, this study measured brachial artery flow‐mediated dilation (FMD) in 42 young (YA, 25 ± 7 yrs), 45 old (OA, 71 ± 7 yrs), and 16 oldest old (OOA, 96 ± 4 yrs) healthy adults. FMD was significantly lower in OA (5.4 ± 2.7 %) and OOA (4.5 ± 2.3%) than YA (7.7 ± 4.0 %), with no difference between OA and OOA, despite the ≈25 yr age difference. Across all age groups, a significant relationship between age and FMD was detected with a two‐segment linear model, identifying a significant change in the rate of FMD decline with age at 97 yrs (slope 1 = −0.040, slope 2 = −0.528 %/yr; r = 0.38). Utilizing this break point of 97 yrs, the OOA were further refined into OOA (93 ± 2 yrs, n = 10) and centenarians (CA, 99 ± 1 yrs, n = 6), with FMD significantly lower in CA (3.2 ± 1.4 %) than OOA (5.3 ± 2.4 %). These findings reveal a steady decline in conduit artery function across the human adult lifespan. However, of importance, successful aging serves to diminish the rate of decline in conduit artery function across the majority of the lifespan until >97 yrs of age, when this decline is greatly exacerbated. This abstract is from the Experimental Biology 2018 Meeting. There is no full text article associated with this abstract published in The FASEB Journal .