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Impaired Platelet Mitochondrial Bioenergetics Is Associated with Hemodynamic Dysfunction in Patient with Peripheral Arterial Occlusive Disease
Author(s) -
Lin MingLu,
Wang JongShyan
Publication year - 2018
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.2018.32.1_supplement.572.2
Subject(s) - medicine , cardiology , hemodynamics , platelet , bioenergetics , platelet activation , pulse wave velocity , blood pressure , mitochondrion , biology , microbiology and biotechnology
Peripheral arterial occlusive disease (PAOD) is a clinical manifestation of systemic atherosclerosis. Circulating platelets can detect and respond to systemic metabolic and inflammatory stressors. The present study aimed to explore whether platelet mitochondrial bioenergetics are associated with the inflammatory indices and hemodynamic functions in patients with PAOD. Sixty‐four individuals diagnosed with PAOD were enrolled randomly in this study. Platelet mitochondrial O 2 consumption rate (OCR) were measured using high‐resolution respirometry. The results demonstrated that PAOD patients with neutrophil‐to‐lymphocyte ratio (NLR)>3.0 and platelet‐to‐lymphocyte ratio (PLR)>150 revealed (i) lesser VO 2peak and the distance to maximal claudication pain, (ii) lower ankle‐brachial pressure index and pulse wave velocity, and (iii) inferior the maximal and reserve OCR capacities in platelet mitochondria than those with NLR<3.0 and PLR<150. Therefore, hemodynamic dysfunction and exercise intolerance are associated with impaired platelet mitochondrial bioenergetics in inflammatory PAOD patients. This abstract is from the Experimental Biology 2018 Meeting. There is no full text article associated with this abstract published in The FASEB Journal .