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Mapping astrocytes to understand development and function of the hindbrain
Author(s) -
Mostafa Hasnaa R.,
Czeisler Catherine,
Otero Jose J.,
Aljuhani Mona
Publication year - 2018
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.2018.32.1_supplement.545.17
Subject(s) - hindbrain , forebrain , neuroscience , neurogenesis , astrocyte , biology , neural development , function (biology) , brain function , lineage (genetic) , microbiology and biotechnology , central nervous system , genetics , gene
Astrocytes, the most abundant glial cells in the mammalian brain, are critical regulators of brain development and physiology through dynamic and often bidirectional interactions with neuronal synapses. The embryonic origin of astrocytes is known to play a major role in defining the functional diversity of astrocytes. Astrogliogenesis is known to temporally follow neurogenesis and neural migration in the forebrain. However, recent studies have demonstrated that the differentiation and distribution of astrocytes may vary between different brain regions. The molecular mechanisms by which astrocytes are specified, interact, and grow in order to shape their complex morphologies are still unknown. A first step in understanding this process is to address how astrocytes develop using lineage markers, including PHOX2B, NKX2.2 , OLIG3 , and ATOH1 , in the murine hindbrain. Characterizing the development of astrocytes will significantly improve the understanding astrocytic contributions to neural function. Furthermore, given their multifaceted quality, it is imperative to attribute astrocytic dysfunction to a wide range of disease states, such as neurodegenerative disorders. Support or Funding Information 3R01hl132355‐01a1s1 This abstract is from the Experimental Biology 2018 Meeting. There is no full text article associated with this abstract published in The FASEB Journal .