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The effects of peroxide exposure on the transfer RNA of radiotrophic C. neoformans
Author(s) -
Kelley Melissa,
Myers Ryan,
Jora Manasses,
Addepalli Balasubramanyam,
Limbach Patrick
Publication year - 2018
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.2018.32.1_supplement.526.36
Subject(s) - transfer rna , cryptococcus neoformans , rna , peroxide , chemistry , biology , computational biology , biochemistry , microbiology and biotechnology , gene , organic chemistry
Cryptococcus neoformans is a radiotrophic fungi capable of surviving in extreme environments. Understanding post‐transcriptional RNA modifications may lead to insight on translational regulation and protein synthesis. Little is known about the role of transfer RNA (tRNA) modifications in C. neoformans . Modification profiles change during oxidative stress and may play biological roles in cell survival. Here, the impact of peroxide exposure on C. neoformans tRNA is investigated through liquid chromatography coupled with mass spectrometry. Support or Funding Information Department of Defense: Defense Threat Reduction Agency (DTRA)University of Cincinnati This abstract is from the Experimental Biology 2018 Meeting. There is no full text article associated with this abstract published in The FASEB Journal .