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Expanding the role of FDO1 in yeast chromosomal biology
Author(s) -
Seman Melissa,
Hoggard Timothy,
Fox Catherine
Publication year - 2018
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.2018.32.1_supplement.522.5
Subject(s) - biology , yeast , genetics , transcription factor , systems biology , genome , computational biology , cell cycle , saccharomyces cerevisiae , mating type , gene
The yeast transcription factor Forkhead 1 (FKH1) has multiple roles in chromosomal biology. Our lab recently discovered a protein‐protein interaction between Fkh1 and Fdo1 that contributes to mating type switching, one of multiple nuclear roles for Fkh1. Little information exists for roles of Fdo1 in yeast, and we were interested in whether Fdo1 has additional roles in chromosomal biology. To this end, we have begun to characterize the yeast cell cycle in a fdo1‐dependent manner. Using flow cytometry, we have uncovered connections between fdo1 and cell cycle progression as well as genome stability. This abstract is from the Experimental Biology 2018 Meeting. There is no full text article associated with this abstract published in The FASEB Journal .