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Protective Effect of Beta vulgaris on Carbon tetrachloride induce Cardiotoxicity of adult Wistar Rat
Author(s) -
OKECHUKWU HOPE,
IHENTUGE CHURCHILL,
EGEONU SOLOMON,
ANIBEZE CHIKE,
NDUKWE GODWIN
Publication year - 2018
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.2018.32.1_supplement.512.8
Subject(s) - carbon tetrachloride , cardiotoxicity , body weight , chemistry , beta (programming language) , toxicity , medicine , traditional medicine , endocrinology , organic chemistry , computer science , programming language
Beta vulgaris a leafy green vegetable consumed throughout the world and traditionally used as an anti‐hyperglycemic nutritional supplement and treatment of various diseases such as cancer, diabetes and liver damage. This study was to investigate the protective effect of beta vulgaris on the heart following Carbon tetrachloride (CCl 4 ) toxicity. Twenty five adult albino wistar rats weighing between 150g and 200g were used in this study. The animals were divided into five groups. Groups A, B, C, D, and E. Groups A and B served as control were injected with paraffin oil for two consecutive days and group B in addition were fed with Beta vulgaris extract alone . Groups C and D were injected with CCl 4 (1.0ml/kg b.w i.p) for two consecutive days and group D fed with Beta vulgaris extract throughout the experimental days. Group E was fed with Beta vulgaris extract throughout the experiment and injected with CCl 4 on the last two days of the experimental period (28 days). At the end of the experimental period, animals were reweighed and sacrificed using chloroform vapour. The heart was harvested and trimmed for histological studies. The results showed a decrease in mean body weight of 5% in group C animals. The heart weight was significantly higher in group C (p<0.05) when compared with groups (A and B) and other experimental groups (D and E). Histological examination (H&E) of the heart in group C animals showed massive destruction of cardiac muscle fibres, tissue inflammation, and hemorrhagic appearance in the heart tissues, while groups A, B and E were normal and group D showed mild vacuoles (apoptosis) and signs of regeneration of cardiac muscle cells. This result shows that Beta vulgaris has the ability to prevent and also restore histological changes in the heart following CCl 4 toxicity. This abstract is from the Experimental Biology 2018 Meeting. There is no full text article associated with this abstract published in The FASEB Journal .