Premium
Migrosome and migrocytosis
Author(s) -
Yu Li,
Jiang Dong,
Jiang Zheng,
Meng Anming
Publication year - 2018
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.2018.32.1_supplement.379.4
Subject(s) - vesicle , extracellular vesicles , microbiology and biotechnology , cytosol , chemistry , secretory vesicle , cell migration , mechanism (biology) , cell , biophysics , biology , biochemistry , physics , membrane , quantum mechanics , enzyme
Cells communicate with each other through secreting and releasing proteins and vesicles. Many cells can migrate. In this study, we report the discovery of migracytosis, a cell migration‐dependent mechanism for releasing cellular contents, and migrasomes, the vesicular structures that mediate migracytosis. As migrating cells move, they leave long tubular strands, called retraction fibers, behind them. Large vesicles, which contain numerous smaller vesicles, grow on the tips and intersections of retraction fibers. These fibers, which connect the vesicles with the main cell body, eventually break, and the vesicles are released into the extracellular space or directly taken up by surrounding cells. Since the formation of these vesicles is migration‐dependent, we named them “migrasomes”. We also found that cytosolic contents can be transported into migrasomes and released from the cell through migrasomes. We named this migration‐dependent release mechanism “migracytosis”. In this seminar, I will discuss our recent progress on the molecular mechanism for migrasome formation and the physiological roles of migrsome.MigrasomeThis abstract is from the Experimental Biology 2018 Meeting. There is no full text article associated with this abstract published in The FASEB Journal .