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Antenatal exposure to secondhand smoke impacts growth and cardiopulmonary energetics in 4‐week‐old mice
Author(s) -
Hirschi Kelsey M.,
Egbert Kaleb,
Clark Christian,
Mella Nate,
Plothow Edward,
Mejia Juan F.,
Arroyo Juan A.,
Reynolds Paul R.
Publication year - 2018
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.2018.32.1_supplement.35.2
Subject(s) - medicine , heart rate , blood pressure , renal function , secondhand smoke , respiratory system , physiology , tobacco smoke , ventilation (architecture) , gestational age , cardiology , pregnancy , biology , environmental health , mechanical engineering , engineering , genetics
Secondhand smoke (SHS) is a well‐established cause of respiratory illness in infants and children who live in environments where exposure is common. Recent studies examining potential effects of antenatal SHS exposure suggest that antenatal exposure to SHS impacts cardiovascular and respiratory function through childhood and may have lifelong ramifications. In the present study, we sought to determine effects of antenatal SHS exposure on 4‐week‐old mice. C57/Bl6 mice (n=8) were exposed to SHS or room air via a nose‐only delivery system (Scireq) beginning on gestational day (dGA) 14.5 to 17.5 dGA. At 4 weeks of age, mice were weighted and blood pressure and heart rate was determined with a tail occlusion cuff (Kent Scientific). Whole body, heart/body and liver/body weights were determined. Lastly, organ‐specific mitochondrial function tests were performed. At 4 weeks of age, antenatal exposure of SHS caused: 1) a significant reduction (p<0.03) in total body weight; 2) significantly elevated systolic (p<0.0002) and diastolic (p<0.004) blood pressure; 3) no differences in the animal's heart rate; 4) significantly decreased heart (p<0.004) and kidney (p<0.0006) weights when indexed to body weight; and 5) significantly decreased oxygen consumption related to cellular respiration in SHS‐exposed hearts and lungs when compared to room air exposed controls. Our results indicate that antenatal exposure to SHS has a detrimental effect on growth rates and cardiopulmonary energetics through the 4 th week of age, or the equivalent of early adolescence. These results may be beneficial in understanding the long‐term effects of antenatal SHS exposure. Support or Funding Information This work was supported by a grant from the Flight Attendant's Medical Research Institute (FAMRI, PRR and JAA) and a BYU Mentoring Environment Grant (JAA and PRR). This abstract is from the Experimental Biology 2018 Meeting. There is no full text article associated with this abstract published in The FASEB Journal .