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Mechanoresponsive skeletal stem cells acquire primitive neural crest identity during distraction osteogenesis
Author(s) -
Longaker Michael
Publication year - 2018
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.2018.32.1_supplement.24.1
Subject(s) - neural crest , regeneration (biology) , biology , stem cell , progenitor cell , regenerative medicine , microbiology and biotechnology , anatomy , neuroscience , multipotent stem cell , embryo
The cellular mode of regeneration in response to mandibular distraction is of great interest, as this represents a successful clinical strategy to elicit the endogenous regenerative potential of postnatal tissue. Much like regeneration of distal digit tip in mice, mandibular distraction enacts the integrated outgrowth of multiple tissues within 2–3 months, reaching a form that is similar to normal mandible in form and function. Our previous studies in the mouse digit tip have reported a lineage restriction of stem/progenitor cells as an evolutionarily conserved paradigm in which de‐differentiation of resident cells into multipotent progenitors does not occur in post‐natal repair and regeneration. Here we provide evidence, for the first time, that controlled mechanical advancement of the lower jaw activates FAK signaling events which unlock gene regulatory programs normally active in cranial neural crest cells during facial morphogenesis, leading to an enhanced regenerative potential of tissue‐resident SSCs in the adult mandible. Support or Funding Information NIH R01 DE026730, Hagey Laboratory for Pediatric Regenerative Medicine, The Gunn/Olivier Fund, Stinehart/Reed award This abstract is from the Experimental Biology 2018 Meeting. There is no full text article associated with this abstract published in The FASEB Journal .