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Sex Differences in Remodeling of the Failing Heart
Author(s) -
Kararigas Georgios
Publication year - 2018
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.2018.32.1_supplement.235.3
Subject(s) - heart failure , pressure overload , medicine , ventricular remodeling , disease , hormone , ejection fraction , menopause , endocrinology , cardiovascular physiology , cardiac hypertrophy , cardiology
Heart failure (HF) is a leading cause of hospitalization and death and can be characterized by either reduced or preserved ejection fraction. Cardiomyopathies like Takotsubo and HF manifest differently between men and women. More men have maladaptive remodeling underlain by higher induction of pro‐fibrotic pathways, while women repress inflammatory pathways. Sex and menopause‐related differences in the incidence and the prognosis of cardiovascular disease have pointed to the sex hormone 17β‐estradiol (E2) and its receptors (ER α and β). Employing the transverse aortic constriction model in mice to study E2‐ and sex‐specific regulation of pressure overload‐induced left ventricular hypertrophy and HF, the E2/ER axis is considered cardioprotective in females. In contrast, E2 exerts deleterious effects in male hearts and cardiac cells. Detailed characterization of the regulation of cardiac (patho)physiology by sex and E2 and elucidation of the underlying mechanisms may lead to the identification of novel therapeutic targets, which may have a wide implication in the development of new and personalized therapies. This abstract is from the Experimental Biology 2018 Meeting. There is no full text article associated with this abstract published in The FASEB Journal .