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Disordered regions as regulators of phase transitions in multivalent proteins
Author(s) -
Pappu Rohit V.
Publication year - 2018
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.2018.32.1_supplement.102.3
Subject(s) - bespoke , frontier , phase (matter) , experimental biology , sequence (biology) , computational biology , nanotechnology , physics , chemistry , political science , biophysics , computer science , biology , materials science , biochemistry , quantum mechanics , law
This talk will present a synthesis of findings from theory, computation, and experiment highlighting the roles of intrinsically disordered regions as regulators and modulators of phase transitions for linear multivalent proteins. These phase transitions determine the organization, dynamics, and functions of membraneless organelles and other biomolecular condensates. The insights obtained are paving the way for designing condensates with bespoke sequence‐encoded phase behavior and material properties. Support or Funding Information This work is supported by the National Science Foundation, the National Institutes of Health, the Human Frontier Science Program, and the St. Jude Children's Research Hospital Research Collaborative. This abstract is from the Experimental Biology 2018 Meeting. There is no full text article associated with this abstract published in The FASEB Journal .