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Impact of hypo‐energetic dieting with different types of macronutrients on ketone and letpin levels
Author(s) -
Moulton C,
Taylor L,
Campbell B,
Kerksick C,
Roberts M,
Rasmussen C,
Kreider R
Publication year - 2006
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.20.5.lb94-a
Subject(s) - dieting , leptin , endocrinology , medicine , ketone bodies , ketone , chemistry , carbohydrate , weight loss , obesity , metabolism , organic chemistry
Ketone and leptin levels are associated with changes in dietary intake and composition. This study examined the acute response of ketone production and leptin to hypo‐energetic dieting with different types of macronutrient profiles. Thirty sedentary, obese women (41.8±11.9 yrs, 165±7 cm, 102.8±20 kg, 46±4 %, 37.4±6.9 kg/m 2 ) consumed either a higher carbohydrate (% CHO: PRO: FAT= 46: 24: 30; n=14) or higher protein (% CHO: PRO: FAT= 24: 46: 30; n=16) hypo‐energetic diet (1,000 kcal/d) for a 7‐day period. Subjects were given prescribed diets developed by a registered dietician in order to provide the desired macronutrient and caloric intakes. Participants provided daily fasting blood samples after 0, 1, 2, 3, 4 and 7 days of dieting for determination of ketone and leptin levels in addition to having their body mass determined. Data were analyzed by repeated measures ANOVA and correlations were calculated for all variables using respective delta values (post – pre values). Dieting significantly (p<0.05) reduced leptin and a significantly increased ketone production with no differences between groups. Changes in bodyweight after 6 days of dieting were significantly correlated to changes in ketone (r= −0.58, p<0.01) and leptin (r= 0.49, p<0.01) levels. Results indicate that the weight loss associated with hypo‐energetic dieting increases ketone production and decreases leptin.