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The proinflammatory state is associated with higher urinary protein excretion in older, non‐diabetic adults living in the community: the InCHIANTI study
Author(s) -
Howard Caitlin,
Ble Alessandro,
Lauretani Fulvio,
Ray Amanda,
Bandinelli Stefania,
Semba Richard,
Ferrucci Luigi
Publication year - 2006
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.20.5.lb91-b
Subject(s) - medicine , proteinuria , proinflammatory cytokine , diabetes mellitus , creatinine , renal function , logistic regression , c reactive protein , urinary system , population , endocrinology , cohort , inflammation , kidney , environmental health
A proinflammatory state is common in older adults and is associated with endothelial dysfunction, metabolic syndrome, atherosclerosis, and sarcopenia. The objective was to determine whether inflammation is associated with higher urinary protein excretion in older non‐diabetic people. A cross‐sectional study was conducted in 82 men and 85 women, aged 65 and older, without diabetes mellitus, from the InCHIANTI study, a population‐based cohort of older adults living in the community. Plasma C‐reactive protein (CRP) and 24‐h urinary protein (24‐UP) excretion were measured. Mean age (SD) was 71.9 (4.5) years. Median CRP was 1.5 μg/mL and 24‐UP was 96.8 mg. 26.9% had 24‐UP >150 mg. The prevalence of proteinuria (24‐UP >150 mg) among participants with CRP < and ≥10 μg/mL was 23.5% and 41.9%, respectively ( P <0.05). Spearman correlation between log e CRP and 24‐UP was r = 16 ( P <0.05). In linear regression models adjusting for age and sex, log e CRP was associated with log e 24‐UP (beta = 0.09, P <0.05), and results were similar after adjusting for creatinine clearance. Adjusting for age, sex, and creatinine clearance, a logistic regression model showed that people with higher CRP had a higher risk of proteinuria (OR 2.31, 95% CI 1.01–5.38, P <0.05). These results suggest that the age‐related proinflammatory state is associated with proteinuria among older, non‐diabetic adults living in the community. Supported by NIA N01‐AG‐5‐0002, R01 AG027012.