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A Study on the Relationship between Uncoupling Protein‐1 (UCP‐1) Genotype and LDL Cholesterol Level in Korean Elementary Boys and Girls
Author(s) -
Lee Myoungsook,
Oh Hyunhee,
Kim Youngyoun
Publication year - 2006
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.20.5.lb91
Subject(s) - endocrinology , medicine , obesity , thermogenesis , genotype , allele , uncoupling protein , body mass index , cholesterol , biology , odds ratio , brown adipose tissue , genetics , gene
Uncoupling protein‐1 (UCP‐1) plays a major role in thermogenesis in brown adipose tissue, and has been implicated in the pathogenesis of obesity and metabolic disorders. The purpose of this study was to estimate the effects of A‐3826G polymorphism of UCP‐1 gene on the obesity parameters with plasma lipid profiles in 115 Korean elementary subjects aged 8–11 years. Anthropometry, body composition, basal metabolic rate (BMR), dietary assessments (24 hours recall method) and UCP‐1 genotyping (PCR‐RFLP method) were done. Serum concentrations of total cholesterol, HDL cholesterol, triglyceride, fasting glucose, insulin and c‐peptide were measured by auto‐biochemical analyzer. The frequencies of UCP‐1 genotype were AA type; 17.7%, AG type; 56.6% and GG type; 25.7%. After sex, age and fat intake were adjusted, weight, BMI, skeletal muscle mass, lean body mass and BMR were significantly higher in AA type compared with AG type. The plasma levels of fasting glucose and LDL cholesterol were significantly higher in AG type compared with AA type (p<0.05). When logistic regression analysis was conducted to find the risk factors of hyper‐ LDLcholesterolemia (>130mg/dL), the prevalence increased of odds ratios from 1.0 ORs for A allele to 6.919 (CI, 1.414–33.859) ORs for G allele of UCP‐1 gene. Therefore, our results suggest that the G allele of UCP‐1 gene was stronger risk factors in hyer‐LDLcholesterolemia than A allele.