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Lipid peroxidation and antioxidant status in preeclamptic and uncomplicated pregnancies
Author(s) -
Kabir Yearul,
Khan Tanzir A,
Howlader Zakir Hossain
Publication year - 2006
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.20.5.lb85-d
Subject(s) - tbars , preeclampsia , lipid peroxidation , antioxidant , vitamin e , blood pressure , medicine , endocrinology , proteinuria , thiobarbituric acid , gestation , lipid profile , chemistry , pregnancy , cholesterol , oxidative stress , biochemistry , biology , kidney , genetics
Lipid peroxidation and antioxidant status of women (20–30 yrs) with preeclampsia (PE, n=25) as compared to uncomplicated normal pregnant (UP, n=22) and non pregnant (NC, n=25) women were studied. Preeclamsia was defined as systolic blood pressure > 140 mmHg or a rise of ≥ mmHg; diastolic blood pressure > 90 mmHg or a rise of ≥15 mmHg; proteinuria of 300 mg/24 hour and antipartum. Subjects with UP were normotensive throughout gestation and had no proteinuria. The blood and 24 hr urine collected during admition for delivery in Dhaka Medical College Hospital, Bangladesh. Blood lipid profile, thiobarbituric acid reactive substances (TBARS), lipid hydroperoxide, total antioxidant status (TAS) and vitamine C level were measured using standard methods. TBARS and lipid hydroperoxide were significantly (p<0.001) increased and TAS and vitamin C levels were decreased (p<0.001) in women with PE compared to the UP group. No differences were observed between the UP and the NC. Cholesterol, TG and LDL levels were elevated and HDL was normal in UP compared to NC. In PE group HDL was lower and TG was elevated compared to UP. The results suggested that oxidants and antioxidant activities are altered during preeclampsia and may play a significant role in its pathophysiology.