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Effects of Astaxanthin on Human Blood Rheology
Author(s) -
Yamashita Eiji,
Takahashi Jiro,
Tsukahara Hiroki
Publication year - 2006
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.20.5.lb85-a
Subject(s) - placebo , astaxanthin , medicine , human blood , helsinki declaration , whole blood , adverse effect , rheology , chemistry , surgery , materials science , informed consent , physiology , pathology , food science , alternative medicine , composite material , carotenoid
Effects of astaxanthin derived from Haematococcus pluvialis (AX) on human blood rheology were investigated in 20 adult Japanese men with a single‐blind method. The experimental group (n=10) was 57.5 ± 9.8 years of age and the placebo group (n=10) was 50.8 ± 13.1 years of age. A blood rheology test that measures whole blood transit time was conducted using heparinized blood of the volunteers by a MC‐FAN apparatus (microchannel array flow analyzer, bloody 6–7; 8736 channels; width 7 micrometer, length 30 micrometer, depth 4.5 micrometer; Hitachi Haramachi Electronics Co., Ltd.). After administration of AX 6mg/day for 10 days, the values of the experimental group were decreased from 52.8 ± 4.9 sec to 47.6 ± 4.2 sec (p<0.01) and a comparison of the values between the experimental (47.6 ± 4.2 sec) and the placebo (54.2 ± 6.7 sec) groups showed a significant difference (p<0.05). There were no adverse effects resulting from the administration of AX 6mg/day for 10 days. Informed consent was obtained from each subject. This study complied with the Declaration of Helsinki.