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Effects of 8 Weeks of Supplementation of the Alleged Aromatase Inhibitor Novedex XTTM on Serum Steroid Hormone Profiles and Clinical Safety Markers in Resistance‐Trained Males.
Author(s) -
wilborn colin,
Taylor Lem,
Campbell Bill,
Willoughby Darryn
Publication year - 2006
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.20.5.lb83-a
Subject(s) - aromatase inhibitor , aromatase , medicine , hormone , endocrinology , steroid , steroid hormone , breast cancer , cancer
The purpose of this study was to examine the effects of a commercially available aromatase inhibitor (Novedex XT™, Gaspari Nutrition, Neptune, NJ) on serum steroid hormone levels and clinical safety markers. Seventeen resistance trained men (182 ± 6.8 cm, 91.5 ± 14.4kg, 26 ± 4.7yrs, 17 ± 6%) were assigned an 8‐wk supplementation protocol consisting of the oral ingestion of either 72 g/d of Novedex XT™ or 72 g/d of placebo. Body composition, blood, and urine samples were taken at baseline and after wks 4, 8, and 11. Using ELISA and EIA, serum samples were assayed for various levels of steroid hormones (total and free testosterone, DHT, estradiol, estrione, estrone, SHBG, LH, and FSH, and cortisol). Data were analyzed by 2‐way repeated measures ANOVA. Analyses showed no significant change in clinical safety markers through urine or serum. Significant differences were seen between groups for total testosterone (p = .00), free testosterone (p = .00), DHT (p = .00), and body composition (p = .05). However, no significant difference was seen in estriol (p = .33), estrone (p = .878), or estradiol (p = .08). The results of this study indicated that there was over a 300% increase it total testosterone and a 600% increase in free testosterone, without any associated increases in any of the three estrogen hormones over eight weeks. Therefore, Novedex XT™ appears to significantly elevate endogenous serum testosterone without increasing estrogen, thereby suggesting a plausible role for this nutritional supplement as an effective aromatase inhibitor.