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Plasma zinc and magnesium concentrations in pregnant women with abnormal glucose tolerance
Author(s) -
De Haene Jessica,
Nguyen Tuan,
Mukherjea Ratna,
De Regil Luz Maria,
King Janet C,
ElKady Dina
Publication year - 2006
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.20.5.lb81-b
Subject(s) - medicine , postprandial , endocrinology , gestational diabetes , impaired glucose tolerance , gestation , magnesium , zinc , diabetes mellitus , pregnancy , chemistry , insulin resistance , biology , organic chemistry , genetics
Plasma zinc and magnesium concentrations in pregnant women with abnormal glucose tolerance Jessica De Haene1, Tuan Nguyen 2, Ratna Mukherjea2, Dina El Kady3, Luz Ma. de Regil 2, Janet C King 1,2. 1Dpt. of Nutrition, 1 Shields Ave., UC Davis, CA, 95616 2 CHORI, 5700 MLK Jr Way, Oakland, CA, 94609, 3 North Shore University Hospital, Manhasset, N.Y., 11030 Circulating levels of zinc (Zn) and magnesium (Mg) are reduced in non‐pregnant diabetic patients compared to controls. Studies of the effects of gestational diabetes on plasma Zn and Mg are limited. We determined plasma Zn (PZn) and PMg concentrations in 45 pregnant women divided into 3 groups: Normal glucose tolerant (NGT) n=7, Impaired glucose tolerant (IGT) n=27 and Gestational Diabetes Mellitus (GDM) n=11; at fasting and at 2 hr postprandially at 26‐28, 32–34 and 36–38 weeks of gestation. Fasting PMg, postprandial PZn and PMg concentrations did not differ among the 3 groups at any time point. Fasting PZn concentrations (50th P) were higher in the GDM group compared to IGT group, 56.9 vs 45.9 ug/dL; p<0.05 at 26–28 wks; 53.6 vs 44.0 ug/dL; p<0.03 at 32–34 wks, and 47.6 vs 38.5 ug/dL; p<0.005 at 36–38 wks. PZn concentrations tended to decline in the third trimester in all groups but only the fall in the IGT group was significant (p<0.04). GDM women have higher rather than lower levels of fasting PZn in the 3rd. trimester compared to women with IGT or NGT. These data suggest that zinc metabolism in GDM differs from that in type 1 or 2 diabetes mellitus. Supported in part by Healthetech Inc.