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Effect of MSG‐induced obesity on phagocytic activity of rat macrophages
Author(s) -
Kanunfre Carla Cristine,
Schemberger Michelle Orane,
Poter Indina Lucia,
Texeira Ana Carolina Oliveira,
Sampaio Sandra Coccuzzo,
Curi Rui
Publication year - 2006
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.20.5.lb27
Subject(s) - monosodium glutamate , endocrinology , medicine , immune system , obesity , opsonin , lipopolysaccharide , chemistry , phagocytosis , immunology
It is controversial whether obesity affects immune function. In this study, the effect of glutamate monosodium (MSG)‐induced obesity on the phagocytic activity of male rat macrophages was evaluated. Obese 180 days old rats presented: reduction of the corporal weight, relative and absolute organ weights, high abdominal and subcutaneous fat deposition, reduced food intakes compared to control (22.6%), increase of serum glucose (29%) and triglycerides (61.4%) concentrations, high lipid peroxidation (38%) and leukocyte differential count was not changed. The MSG‐induced obesity did not affect the phagocytic activity using opsonized particles (zimosan), but increased by 46% the phagocytic activity using not opsonized particles (by optic microscopy). These findings are of great importance since obesity is the major risk factor for several chronic diseases. Other studies are required to understand the mechanisms involved. Supported by Araucaria Foundation and CNPq.