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SLEEP DEPRIVATION AFFECTS FOOD INTAKE ALTERING HEPATIC GLYCOGEN STORES
Author(s) -
Martins Paulo Jose Forcina,
D'Almeida Vania,
Souza Fernanda Gonçalves,
Tufik Sergio
Publication year - 2006
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.20.5.lb26-a
Subject(s) - endocrinology , medicine , leptin , glycogen , corticosterone , cholesterol , ghrelin , food intake , weight loss , glucagon , hormone , body weight , sleep deprivation , chemistry , biology , obesity , circadian rhythm
Our objective was to study the body weight homeostatic control of sleep deprived rats, assessing their feeding behavior, hormonal and metabolites responses. Male rats, living under controlled conditions, were housed individually for each experiment and signed as control (CTR, n=10), sleep deprived for 96h by the platform technique (SD‐96h, n=10) and rats SD‐96h recovered for 24h (REB, n=10) groups. In the first experiment animals were fed with chow pellets (fCP), while in the second they were fed with a liquid diet (fLD). After correcting by food spillage, food intake was reduced in fCP rats, which lead to larger body weight (BW) decrease. In addition, we found lower stomach weight, liver glycogen (LG) and triacylglycerol, while ketones bodies and LDL cholesterol showed higher levels in SD‐96h. Body weight, stomach weight and ketones bodies were not recovered in REB group. On the other hand, fLD rats have shown increased food intake during SD, which was followed by mild BW reduction. Further, we found a reduction in LG, HDL cholesterol and triacylglycerol, while LDL cholesterol levels increased. Only HDL cholesterol was not recovered in REB group. Reinforcing the evidences that fCP rats have exacerbated metabolic changes, we found diminished insulin, leptin and increased glucagon, ghrelin and corticosterone levels in SD‐96h group, while only a decreased leptin and higher corticosterone levels were found in fLD rats. Rats fed with fCP are unable to have all food that they seek, which exacerbate the negative energy balance induced by SD. Finally, LG was the main factor related to feeding behavior in rats.