Premium
The effects of uni‐ and bi‐lateral orchidectomy and testosterone replacement on glucose homeostasis in male rats
Author(s) -
BarazandehAsl Esmaeel
Publication year - 2006
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.20.5.lb25-c
Subject(s) - medicine , endocrinology , glucose homeostasis , testosterone (patch) , serum glucose , homeostasis , adult male , hormone , chemistry , insulin , insulin resistance
Background & Aims Male steroids influence glucose homeostasis in various biochemical and physiological ways. This study evaluates the effects of gonadectomy and testosterone replacement on serum glucose in male rats. Material and Methods Testosterone enantate (10 0r 50 mg/kg/day) was injected intraperiotenally. Orchidectomy was performer based on standard methods. After 4 weeks, blood samples were collected and serum glucose was measured and compared statistically between groups (ANOVA). Results Serum glucose was decreased in uni‐ and bi‐orchidectomised rats. Testosterone replacement (50 mg/kg/day) in bi‐orchidectomised rats caused to increasing of serum glucose to normal level (P<0.05). Testosterone administration (10 mg/kg/day) resulted in increasing of serum glucose in non orchidectomised animals compared with control group (P<0.05). Conclusion The results of our study show that male steroids significantly modulate glucose homeostasis since uni‐ and bi‐orchidectomy resulted in decreasing of serum glucose. On the other hand, our findings demonstrated that testosterone is a serum glucose enhancer hormone.