Premium
Oxidative stress contributes to the reduced basal limb blood flow in estrogen‐deficient postmenopausal women
Author(s) -
Moreau Kerrie L,
Depaulis Ashley R,
Gavin Kathleen M,
Seals Douglas R
Publication year - 2006
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.20.5.lb14
Subject(s) - medicine , oxidative stress , endocrinology , estrogen , basal (medicine) , menopause , diabetes mellitus
Basal femoral artery blood flow (FemBF) and vascular conductance (FemVC) are reduced in estrogen‐deficient postmenopausal vs. premenopausal women. The underlying mechanisms are unknown, but oxidative stress could be involved. To determine this, 9 premenopausal (23±1 years [mean±SE]; PRE) and 20 estrogen‐deficient postmenopausal (55±1; POST) healthy women were studied. During baseline control, oxidized LDL, a marker of oxidative stress, was 50% greater in POST (P<0.001), and FemBF (duplex ultrasound) was 30% lower in POST because of a 36% lower FemVC (P<0.0001); mean arterial pressure (MAP) was not different. Intravenous administration of a supra‐physiological dose of the antioxidant vitamin C increased FemBF by 16% in POST because of a 16% increase in FemVC (both P<0.001), but did not affect FemBF in PRE or MAP in either group. In the pooled subjects, the change in FemBF and FemVC with vitamin C were related to baseline plasma oxidized LDL (r=0.45 and 0.51, P<0.005), total body fat (r=0.48, P<0.005) and waist‐to‐hip ratio (r=0.44 P<0.01). Oxidative stress may contribute to reduced basal FemBF in estrogen‐deficient postmenopausal women via chronic vasoconstriction related to increased total and abdominal adiposity. Supported by NIH AG20683, AG22241, AG13038, RR00051.