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The Protective effects of water extracts of the Korean remedy, ZoaGumHwan (ZGH), on the angiotensin II‐induced damage in HUVECs
Author(s) -
Ko Yu Jin,
Park Byung Chul,
Shin Heung Mook,
Kim JungAe
Publication year - 2006
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.20.5.lb106
Subject(s) - oxidative stress , angiotensin ii , reactive oxygen species , pharmacology , pathogenesis , umbilical vein , chemistry , downregulation and upregulation , in vitro , coptis chinensis , traditional medicine , medicine , immunology , biochemistry , receptor , traditional chinese medicine , alternative medicine , pathology , gene
It is well known that hypertension serves as a risk factor for atherosclerosis which is characterized as an inflammatory disease involving the upregulation of mononuclear leukocyte recruiting mechanisms in response to oxidative stress in the vessel wall. Among many factors, angiotensin II (Ang II) is the most characterized humoral factor that plays an important role in the pathogenesis of atherosclerosis and hypertension. Here we report that water extracts of the Korean herbal remedy, ZoaGumHwan (ZGH), which is composed of roots of Coptis chinensis Franch and fruits of Evodia officinalis Dode with the ratio of 6 to 1, dose‐dependently inhibited the Ang II‐induced generation of reactive oxygen species in human umbilical venous endothelial cells (HUVECs). In addition, the extracts significantly blocked the in vitro oxidation of low density lipoproteins (LDL). However, the extract of ZGH dose‐dependently augmented the harmful effect of oxidized LDL on the viability of HUVECs. Thus, Korean herbal remedy, ZGH, seems to have a protective effect against Ang II‐induced stimuli.