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Compensatory Growth And Blood Pressure Using Non‐Invasive And Telemetry Techniques In Yucatan Mini‐Pigs
Author(s) -
Myrie Semone B,
McKnight Leslie L,
Van Vliet Bruce N,
Bertolo Robert F
Publication year - 2006
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.20.5.lb104-c
Subject(s) - telemetry , blood pressure , heart rate , medicine , diastole , cardiology , cuff , mean arterial pressure , pulse pressure , mean blood pressure , surgery , engineering , aerospace engineering
In epidemiological studies, low birth‐weight followed by catch‐up growth is associated with an increased risk of hypertension and cardiovascular disease in adulthood. Runt Yucatan miniature pigs (<800g) were paired with the largest same sex littermate (>1000g) and fed milk replacer ad libitum from 3 to 31 days of age; thereafter they were fed standard chow ad libitum. During the first 4 wk, runts demonstrated catch‐up growth and by 8 months of age their body weights were not different than their littermates. In order to monitor hypertension, we used the noninvasive blood pressure (NIBP) technique using a foot cuff at 8 months of age. We subsequently measured BP using telemetry. With NIBP, systolic, diastolic and mean arterial pressure (MAP) (runt: 93 ± 12, littermate: 92± 10 mmHg) were not different between groups. However, for all pigs, none of these data correlated with respective telemetry data. NIBP heart rate tended to correlate with peak heart rate using telemetry (P=0.08) but blood pressure estimates tended to be negatively correlated (P=0.11). Using telemetry data for all pigs, unimodal distributions over 24 h were observed for MAP (117± 7 mmHg), heart rate (87± 5 bpm), systolic (140± 7 mmHg), diastolic (97± 7 mmHg) and pulse (43 ± 6 mmHg) pressures. Although blood pressure parameters were not different between runts and littermates, relative size of left ventricles in runts were larger than littermates. BP telemetry data during a salt challenge will also be presented. We have established a pig model of compensatory growth which can be used to further investigate early origins of cardiovascular disease (Supported by CIHR).