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The role of inflammation in estrogen‐induced extracellular matrix turnover and MMP regulation in the immature rat uterus
Author(s) -
Russo Louise Ann,
Vishnevsky Oleg,
Caruso Joseph,
Gardner Russell
Publication year - 2006
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.20.5.a969-b
Subject(s) - estrogen , endocrinology , extracellular matrix , matrix metalloproteinase , medicine , uterus , endometrium , inflammation , chemistry , stroma , biology , microbiology and biotechnology , immunohistochemistry
The immature rat uterus has long been used as a model system to study estrogen‐based regulation of endometrial remodeling and matrix metalloproteinase (MMP) regulation. During estrogen‐induced uterine growth, an inflammatory‐like response has been documented involving fluid and leukocyte infiltration into the endometrium. This study examined the role of prostaglandins, critical inflammatory mediators, in this process. Pre‐treatment with the COX enzyme inhibitor, indomethacin, produced a dramatic inhibition of estrogen‐induced matrix turnover in the endometrial stroma as compared to control tissues as assessed via transmission electron microscopy. In addition, indomethacin treatment resulted in a decreased expression of MMP‐7 and MMP‐9, but an increase in levels of MMP‐3. Pre‐treatment with the anti‐inflammatory glucocorticoid, dexamethasone, also produced significant inhibition of extracellular matrix remodeling in estrogen treated uterine tissues. These data collectively indicate a critical role for the inflammatory response in estrogen induced uterine growth and remodeling.