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Effect of Lysophosphatidylserine on Glucose Regulation
Author(s) -
Kwon Taewan,
Yea Kyungmoo,
Suh PannGhill,
Ryu Sung Ho
Publication year - 2006
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.20.5.a956-d
Subject(s) - glucose uptake , medicine , endocrinology , chemistry , adipose tissue , insulin , tyrosine phosphorylation , snf3 , 3t3 l1 , protein kinase b , phosphorylation , carbohydrate metabolism , adipocyte , biology , biochemistry
In addition to insulin, multiple other hormones or physiologic conditions are capable of stimulating glucose uptake. In the search for novel factor, which can promote glucose uptake, it was observed that lysophosphatidylserine(LPS) increased glucose uptake in differentiated 3T3‐L1 adipocytes. We found that LPS stimulated glucose uptake with dose‐ and time‐dependent manner in 3T3‐L1 adipocytes. LPS increases tyrosine phosphorylation of Akt in adipose tissue and muscle. The effect of LPS on glucose uptake was blocked by LY294002. Furthermore, administration of LPS to male ICR mice resulted in significant lowering in blood glucose levels. These results show that LPS stimulates glucose uptake in 3T3‐L1 and lowers blood glucose levels in mice through a mechanism which is PI3‐kinase dependent signaling pathway.