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TETRAZOLES (5‐amino‐tetrazolo[1,5‐c]pirimidin‐7ol) INDUCED GENOTOXIC EFFECT IN LYMPHOCYTESTETRAZOLES (5‐amino‐tetrazolo[1,5‐c]pirimidin‐7ol) INDUCED GENOTOXIC EFFECT IN LYMPHOCYTES
Author(s) -
Kurteshi Kemajl Hysen,
Haziri A.,
Govori S.,
Letaj K.,
Hoxha M.,
Muzaferovic S.
Publication year - 2006
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.20.5.a949
Subject(s) - genotoxicity , micronucleus , micronucleus test , in vitro , chemistry , positive control , microbiology and biotechnology , pharmacology , biology , biochemistry , medicine , toxicity , traditional medicine , organic chemistry
The genotoxicity of new synthetized tetrazoles(5‐amino‐tetrazolo[1,5‐c] pirimidin‐7ol) was studied(125 μg/ml) in vitro in peripheral human lymphocytes. Frequency of apoptic cells at lymphocytes treated by terazoles was higher, statisticaly significant, compare with control. Frequency of necrotic cells at lymphocytes treated by terazoles was higher, compare with control. Frequency of micronucleus(MN) at binucleted cells (BN‐cells)at human lymphocytes, treated by terazoles was higher, but not statistically significant, compare with control. According these investigation we suggested that tetrazoles are genotoxic.