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Regulation of Phospholipase D by dynamin in the integrin signaling.
Author(s) -
Kim Jong Min
Publication year - 2006
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.20.5.a935-a
Subject(s) - dynamin , microbiology and biotechnology , integrin , phospholipase c , phospholipase d , phospholipase , chemistry , signal transduction , biology , receptor , endocytosis , biochemistry , enzyme
Dynamin has been considered as a mechanochemical enzyme, which is involved in endocytosis. However, recently, there were reports which highlight dynamin's role as a regulator such as controlling of cell spreading. There are also evidences that PLD activity is important in the cell spreading. All these previous findings imply the relationship of PLD and dynamin within the integrin signaling pathway. Here, we confirmed that the dominant‐negative K44A dynamin inhibited cell spreading. It was also verified that the significance of PLD activity in cell spreading. Altogether, we found out that dynamin is involved in the integrin mediated PLD activity, which is the first to report the role of dynamin in the integrin mediated PLD signaling. This, in turn, suggests possible explanation of the link between mechanochemical and regulatory activity of dynamin and provides evidences of dynamin's role of intracellular coordinator.