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The SYN3 mutation affects megagametogenesis and seed development in Arabidopsis thaliana
Author(s) -
jiang ling,
Xia Ming,
Makaroff Christopher A.
Publication year - 2006
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.20.5.a894-c
Subject(s) - cohesin , establishment of sister chromatid cohesion , sister chromatids , meiosis , biology , mitosis , chromosome segregation , nucleolus , genetics , kinetochore , microbiology and biotechnology , meiocyte , arabidopsis , chromatid , gene , chromosome , mutant , cytoplasm
SCC1 and REC8 represent the cohesin complex kleisin subunits. They are essential for the formation and proper release of sister chromatid cohesion during mitosis and meiosis. Arabidopsis contains four SCC1‐like genes (SYN genes). SYN1 is essential for meiosis, while SYN2 and SYN4 appear to function in mitosis. Analysis of SYN3 indicates that it does not function as a typical cohesin protein, but rather has evolved a new novel role in plant cells. SYN3 localizes in nucleolus in both meiotic and mitotic cells. Furthermore, analysis of a SYN3 knockout mutation has demonstrated that it is required for megagametogenesis and seed development. These results indicate that SYN3 is not part of the cohesin complex, but rather raise the possibility that SYN3 may be involved in regulating rRNA gene dosage control and possibly nucleolar dominance. This project was supported by a grant from NSF (MCB‐0322171).