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Interaction of fibroblasts and myocytes in postnatal remodeling
Author(s) -
Borg Thomas K
Publication year - 2006
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.20.5.a846-b
Subject(s) - myocyte , cardiac myocyte , fibroblast , microbiology and biotechnology , medicine , biology , cell culture , genetics
Most studies on cardiac growth and development have focused on the cardiac myocyte, yet the myocyte makes up only 30% of the cells of the heart. The cardiac fibroblast is the predominate cell type of the heart and has recently been shown to directly interact with cardiac myocytes. Signaling between myocytes and fibroblasts involves the integration of mechanical, chemical and electrical signals. This signaling is critical for growth of the postnatal heart as well as in response to pathophysiological signals that regulate cardiac remodeling. This presentation will review the interaction of fibroblasts and myocytes as well as the role of this interaction in cardiac remodeling in normal growth and disease.