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Cardiovascular adjustments to hemorrhage in diet‐induced obese rats
Author(s) -
Silveira Simonton Andrade,
Lima Daniel Carvalho,
Carmo Santos Milene Cristina,
Mello Bruno,
Coimbra Cândido Celso
Publication year - 2006
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.20.5.a833-c
Subject(s) - medicine , endocrinology , femoral artery , carotid arteries , anesthesia
The aim of this study was to assess the lipids parameters and cardiovascular response to hemorrhage in rat obesity‐model induced by hypercaloric diet. Male Wistar rats (21–30 days old), where fed either a chow (control, n=10, CG) or high palatability diet (PD, n=10, 33% of condensed milk, 33% of chow pellet, 7% of sugar and 8.6% of water) for 9 weeks. 5 rats of each group were sacrificed, blood samples were collected and had their adipose pads measured. The remaining 10 animals (CG and PD groups) bearing a chronic jugular catheter for hemorrhage and polyethylene cannulae inserted into the left femoral artery for cardiovascular monitoring were submitted to hemorrhage (1.2 mL/100g body wt./2min). Our data showed that the adiposity index and the fat pads was greater in PD than GC (p<0.05), as well as plasma triacylglycerol concentration that was 3 fold greater than GC. The hypotension induced by hemorrhage was more intense in PD than GC (PD: 36.4 ± 3.2 mmHg vs CG: 66.4 ± 7.7 mmHg, p<0.05). Our results show that diet‐induced obese rats were more sensitive to hypotension hemorrhage. Supported by: CNPq; FAPEMIG.