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Central enterostatin decreases feed while peripheral enterostatin stimulates feed intake in chicks
Author(s) -
Peacock Hunter Lewis,
Pittman Bryan Hosken,
Cline Mark Andrew
Publication year - 2006
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.20.5.a831-d
Subject(s) - water intake , appetite , medicine , chemistry , zoology , endocrinology , food intake , sed , biology
Enterostatin is a 5‐residue peptide formed during activation of colipase, and reduces feed intake in mammals. The effect of enterostatin in avians is unknown. Thus we conducted experiments to determine the effects of central and peripheral enterostatin on feed and water intake in 4 day post hatch chicks. In experiment 1 chicks randomly received intracerebroventricular injections of 0, 2.0, 8.0, 32.0 microg enterostatin. Feed and water intake were recorded every 30 min for 180 min post injection. Chicks responded with a linear dose dependant decrease in feed intake up to 120 min post injection. Water intake was not effected by treatment. In experiment 2 chicks randomly received intraperitoneal injections of 0, 10.0, 20.0, 40.0 micorg enterostatin. Feed and water intake were recorded every 30 min for 180 min. Chicks responded with a quadratic increase in feed intake that had diminished by 90 min post injection. Water intake was not effected. Thus we conclude that central enterostatin induces it stereotypical response in chicks by decreasing feed intake. However, the peripheral route of administration results in an increase in feed intake. Apparently the effects of enterostatin in chicks differ from mammals. These results may provide insight for the development of a pharmacological strategy to reduce appetite in other species including humans. This research was funded by Radford University.