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ICV galanin‐like peptide increases metabolic rate in male rats
Author(s) -
Babcock Lindy,
Rodriquez Carla,
Barney Christopher C.,
Fraley Gregory
Publication year - 2006
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.20.5.a830-d
Subject(s) - medicine , endocrinology , galanin , energy expenditure , food intake , neuropeptide , chemistry , corticosterone , body weight , food consumption , hormone , receptor , agricultural economics , economics
Galanin‐Like Peptide (GALP) is a hypothalamic neuromediator between metabolism and reproduction. GALP is known to stimulate reproduction and alter food intake and body weight in multiple species. The regulation of body weight involves control of both energy intake and energy expenditure. Since GALP is known to alter food intake, we hypothesized that GALP would increase metabolic rate. Male Sprague Dawley rats were implanted with intracerebroventricular cannulae and abdominal temperature transmitters. Following injection with either 5 nmol of GALP or vehicle, the oxygen consumption of each rat was monitored for 8 hours; and food intake, core temperature, and activity were monitored for 23 hours. GALP significantly increased oxygen consumption without having a significant effect on activity. GALP increased core temperature during the photophase and reduced food intake over 23 hours. In a second set of experiments, the rats were injected with 5 nmol of GALP or vehicle and blood samples obtained two hours later. In these experiments, GALP significantly increased plasma LH concentration without altering plasma corticosterone concentration. GALP appears to increase energy expenditure in addition to decreasing energy input and thus may play an important role in the hypothalamic regulation of body weight. Supported by a Merck/AAAS USRP award, award KO1‐DK‐066238 from NIH, and NSF REU grant DBI‐0139035.